CoQ10 is a compound that is produced by the human body and stored in the mitochondria of cells. (NCBI2) *
Mitochondria are responsible for producing energy in cells. They also protect cells from oxidative damage (so-called antioxidant activity), pathogenic bacteria and viruses. (NCBI3)*
CoQ10 production decreases with age. This is why older people are more likely to be deficient in this compound.
Studies have shown that CoQ10 plays several key roles in the human body. One of its main functions is the production of energy in cells. It is involved in the production of ATP ** (adenosine triphosphate), which is responsible for the transfer of energy between cells. (NCBI2)*. Its other crucial role is to serve as an antioxidant and protect cells from oxidative damage. Which is proven by research (NCBI2, NCBI5)*
Excessive free radicals lead to oxidative damage (cell damage) that can interfere with the normal functioning of the cells. To some extent, this is the cause of many health problems. (NCBI6) *
CoQ10 is contained in every cell of our body. However, the highest concentration is found in organs with high energy needs, such as the heart, kidneys, lungs and liver. (NCBI7)*
Heart failure in many cases is a consequence of other heart conditions such as coronary artery disease and high blood pressure. (NBCI8) *
These conditions can lead to oxidative cell damage and inflammation of the veins and arteries. (NBCI8, NBCI9)*. Heart failure occurs when these problems affect the heart to the extent that it prevents it from working properly or pumping blood. (NBCI8)*.
Some heart failure products have unwanted side effects, such as low blood pressure. Others may even cause a decrease in CoQ10 levels in the body.
In a study of 420 people with heart failure, taking CoQ10 for 2 years improved their condition and reduced the risk of death from heart problems. You can see the survey data here (NBCI11)*
Another study, conducted with 641 people treated with CoQ10 and placebo, demonstrated the beneficial effect of co-administration. The conclusion at the end of the study was that people taking CoQ10 were rarely hospitalized with heart failure and had fewer complications. (NBCI12)*
From our studies, we can summarize that taking CoQ10 can:
Female fertility decreases with age due to the decrease in the number and quality of eggs. CoQ10 is directly involved in this process. With age, CoQ10 decreases in the body, making it less effective at protecting eggs from oxidative damage. (NCBI13)*. Taking CoQ10 as a dietary supplement can help, and even reverse, this age-related decline. Namely - to increase the quantity and quality of eggs.
Similarly, male sperm are sensitive to oxidative damage, which can lead to a decrease in sperm count, poor sperm quality and infertility. This is evidenced by the research done. (NCBI14, NCBI15)*. Studies in this area have proven that CoQ10 intake can improve the quality, activity and concentration of sperm by increasing antioxidant protection. (NCBI15, NCBI16)*
SUMMARY: The antioxidant properties of CoQ10 may improve sperm quality. (NCBI14, NCBI15)*. Also it may increase the quantity and quality of egg cells in females many times over. (NCBI13)*.
The skin is the largest organ in the body. This makes it quite vulnerable to external factors that contribute to aging.
Some of these factors may be internal or external. Internal adverse factors include cellular damage or hormonal imbalance. External factors include natural interference, such as: UV rays, air pollution, etc. (NCBI17)*
The adverse factors listed above can lead to dehydration of the skin and reduce its protection against the harmful effects of the environment, as well as thinning of the layers of the skin. (NCBI17, NCBI18) *
Applying CoQ10 directly to the skin may reduce damage by internal and internal agents. The mechanism of action is by increasing the energy production in the skin cells. Promotion of antioxidant protection. (NCBI19)*
Clinical studies have shown that CoQ10 applied directly to the skin reduces the oxidative damage to cells. It may also reduce the depth of wrinkles caused by UV rays (NCBI20)*.
Last but not least, people with low CoQ10 levels are at greater risk of diseases such as skin cancer. (NCBI21)
SUMMARY: When applied directly to the skin, CoQ10 may reduce sun damage and increase antioxidant protection. Supplemental administration of CoQ10 may also help to reduce the risk of skin cancer, as demonstrated by the following studies. (NCBI21)*
As noted above, impaired mitochondrial function in cells can lead to:
This can lead to a decrease in energy in brain cells and even to migraines. This is evidenced by the research done (NCBI22)*. CoQ10 has been shown to improve mitochondrial function in brain cells and help reduce inflammation that occurs during migraines. (NCBI23)*
A study has shown that taking CoQ10 as a dietary supplement is three times more effective than placebo and helps reduce the incidence of headaches. (NCBI24)*. CoQ10 deficiency has been observed in migraine sufferers.
Another study found that fewer and less severe headaches were seen in 1550 people with low CoQ10 levels after prolonged use of the compound. (NCBI25)*. What's more - taking CoQ10 may not only help reduce the symptoms of migraines, but may also prevent them. This is evidenced by the studies done. (NCBI26)*
SUMMARY: Supplementing CoQ10 as a dietary supplement and improving mitochondrial function may help prevent and alleviate migraines.
Free radical accumulation may impair muscle function. This can contribute to a faster onset of fatigue during exercise and a more difficult recovery afterwards. (NCBI27)*. Impaired mitochondrial function can reduce muscle energy, which causes a decrease in muscle performance in physical activity. This is evidenced by the research done (NCBI28, NCBI29)*
CoQ10 promotes physical performance by reducing free radicals in muscle cells and improving mitochondrial function. (NCBI30)*
There is a study on Copp10 examining the effects of CoQ10 on physical activity. People taking 1200 mg CoQ10 daily for 60 days show a decrease in free radicals in cells (NCBI31)*. Also, supplemental intake of CoQ10 can increase energy during exercise and reduce fatigue. This also improves the effectiveness of the exercises. (NCBI32, NCBI33, NCBI34) *
SUMMARY: Exercise can be influenced by free radical accumulation and mitochondrial dysfunction (impaired mitochondrial function in cells) in muscle cells. CoQ10 may help reduce levels of free radicals accumulated. It may increase exercise efficiency and reduces fatigue.
As already mentioned, the accumulation of free radicals damages cells. This can lead to metabolic diseases such as diabetes. This is evidenced by the study published on August 15, 2017. (NCBI35)*
Mitochondrial malfunctioning is also associated with insulin resistance. (NCBI35)*
Studies with people with type 2 diabetes have shown that CoQ10 improves insulin sensitivity and regulates blood sugar (NCBI36)*
The additional use of CoQ10 as a dietary supplement may help to increase the blood concentration of CoQ10 in the diabetic people, who generally have low levels of this compound, at times as high. (NCBI37, NCBI38)*
A study, conducted with people with type 2 diabetes and receiving CoQ10 for 12 weeks, showed improvements in the performance of their studies. Significant decrease in blood glucose and hemoglobin A1C (glycated hemoglobin) levels (NCBI39)*
Taking CoQ10 as a nutritional supplement may help to break down fat and reduce the buildup of fat cells, leading to obesity or type 2 diabetes (NCBI40)*
SUMMARY: Supplemental intake of CoQ10 may help increase insulin sensitivity and lower blood glucose levels in people with diabetes, as well as protect healthy people from obesity at the cellular level.
If your body is unable to fight free radical accumulation, the structure of your cells may be damaged, increasing the risk of malignancies (some cancers) (NCBI41, NCBI42)*
As mentioned above, CoQ10 may protect cells from free radical accumulation and stimulate cellular energy production. In this way, it may also promote their healing. (NCBI42, NCBI43)*
In people diagnosed with cancer, there is a decrease in CoQ10 levels. Low levels of CoQ10 are associated with up to 53.3% higher risk of cancer. Due to the shortage of k10, the prognoses for different types of malignancies are: (NCBI43, NCBI44, NCBI45)*
A study suggests that supplementing with CoQ10 may help reduce the recurrence of malignancy. (NCBI46) *
SUMMARY: CoQ10 plays an important role in protecting cellular DNA and preserving cells that are highly associated with the prevention and prevention of the recurrence of malignancies.
Mitochondria are the main source of energy in brain cells.
There is a decline in mitochondrial function with age. Complete mitochondrial dysfunction can kill brain cells and cause diseases like Alzheimer's and Parkinson's. (NCBI47) *
Unfortunately, the brain is very susceptible to free radical accumulation in cells due to its high fatty acid content and high oxygen demand.
This accumulation of free radicals increases the production of harmful compounds that can interfere with memory and physical function. (NCBI48, NCBI49)*. With its antioxidant action, the intake of CoQ10 may reduce the formation of these harmful compounds. It may also delay the development of diseases such as Alzheimer's and Parkinson's. The following studies support this: (NCBI50, NCBI51)*
SUMMARY: The extra intake of CoQ10 has been shown to help protect brain cells from the accumulation of free radicals in them. It may reduce the effects of harmful compounds that can lead to brain diseases.
Of all the organs in the human body, the lungs have the highest contact with oxygen. This makes them very susceptible to free radical accumulation.
The modern polluted environment and the accumulation of particulate matter in the air lead to increased oxidative damage in the lungs. Poor antioxidant protection and low levels of CoQ10 in lung cells can lead to lung disease. Some of these include asthma, various forms of bronchitis, complications after colds and flu, and chronic obstructive pulmonary disease. (COPD)** (NCBI52)*. People with these conditions have been shown to have lower CoQ10 levels. (NCBI53, NCBI54)*
A study shows that taking CoQ10 as a dietary supplement may reduce inflammation in people with asthma, as well as their need for steroid medication to treat it (NCBI55)*
Another study shows that supplementation with CoQ10 by people with COPD has seen an improvement in their physical performance. The reason for this is the better antioxidant action that occurs in the tissues and the improvement in heart rate. (NCBI56)*
SUMMARY: Due to the polluted environment, the release of particulate matter into the air and the presence of numerous sources of harmful emissions, our lungs are subject to constant stress and pollution. Therefore, it is recommended to take CoQ10 as a dietary supplement. As shown in the studies described above, CoQ10 can reduce the accumulation of free radicals in the lung cells that lead to various lung diseases.
The standard dose of CoQ10 ranges from 90 mg to 200 mg per day. Doses up to 500 mg are also well tolerated by the body. In several studies, even higher doses without side effects were used. (NCBI59, NCBI60, NCBI61)*
CoQ10 is a fat soluble compound and is slowly absorbed by the body. Taking it with food can help the body absorb it up to three times faster than taking it without food. (NCBI2, NCBI62)* For this reason, our product Pure Gold Q10 is dissolved in apricot oil. One of the highest quality fats, beneficial to the human body.
With an intake of 1200 mg CoQ10 for 16 months, no side effects were observed on the overall function of the cells and body. (NCBI51)*
CoQ10 + Food = CoQ103
CoQ10 - Food = CoQ10
The human body does not store CoQ10. Therefore, it is recommended that its intake be prolonged in order to reap the benefits of it. CoQ10 is one of the few nutritional supplements that can be taken year-round, following the recommended daily intake. (NCBI58, NCBI66)*
The supplemental intake of CoQ10 is well absorbed by the human body and has very low toxicity levels. (NCBI58) *. This toxicity was monitored in a study of humans receiving 1200 mg CoQ10 for 16 months. (NCBI51)*. Therefore, for side effects after CoQ10 administration, a reduction in the daily dose to 3 smaller doses is recommended.
SUMMARY: Because CoQ10 is fat soluble, it is recommended that it be taken with food or combined with oils to improve its absorption.
Sources of information:
These studies were done by the US National Institutes of Health.
National Center for Biotechnology Information United States of America - National Center for Biotechnology informatio U.S. - NCBI
United States National Library of Medicine - U.S. National Library of Medicine - NLM
National Institutes of Health United States of America National Institute of Health - NIH
Serving size: 1 softgel capsule
Supply: 120 days
Per container: 120 softgel capsules
Active substance per serving size - 280 mg
Per serving size - 1 softgel capsule:
Coenzyme Q10 - 50 mg
Green tea extract - 11.5 mg
Apricot Oil - 168.5 mg
Beeswax - 15 mg
Sunflower lecithin - 35 mg
Per daily dose* - 1 softgel capsule:
Coenzyme Q10 - 50 mg
Green tea extract - 11.5 mg
Apricot Oil - 168.5 mg
Beeswax - 15 mg
Sunflower lecithin - 35 mg
Effect: Has a beneficial effect on the symptoms of magnesium deficiency.
Ingredients: Coenzyme Q10, Green tea extract, Apricot Oil, Beeswax, Sunflower lecithin, softgel shell.
*Suggested daily intake: Take 1 softgel daily with meal, but no more than 3 softgels daily.
Suggested intake period: When keeping the prescripted daily dose, there is no limit for the period of intake.
*This product is not intended to diagnose, treat, cure or prevent any disease.
*Do not exceed the recommended daily intake.
*Do not use if you are a pregnant or breastfeeding woman.
*Food supplements must not replace a balanced and varied diet and a healthy lifestyle.
*Consult with your doctor if you have an underlying medical condition (e.g. diabetes, epilepsy, hyperthyroidism), or if you are on medication.
Caution: If you experience any kind of discomfort while taking this product, please stop taking it immediately.
Storage: Store in a cool, dry and protected from a direct sunlight place with a temperature up to 25°C. Keep out of reach of children.